There is a release of norepinephrine from the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors inside the dorsal horn to lower afferent discomfort transmission and produce analgesia. Consequently, medications like clonidine that concentrate on alpha-2 receptors can affect the transmission of ache. Clonidine is dispersed in breast milk; https://garretteyogw.ampblogs.com/onolidine-fundamentals-explained-72487195